The results were significant: At 48 weeks, participants receiving the 12 mg dose achieved a mean weight reduction of 24.2% (approximately 58 pounds or 26.2 kg) 100% of participants on the 8 mg or 12 mg doses lost at least 5% of their body weight More than 90% of participants on the 12 mg dose lost at least 10% of their body weight Nearly half of participants on the highest dose lost 25% or more of their body weight The study also showed improvements in cardiometabolic markers including blood pressure, triglycerides, LDL cholesterol, and fasting glucose
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Plus, vitamin B12 accumulation by the fetus has been shown to be rate limited to about 0.1 to 0.2 mcg per day
Commonly reported side effects (incidence 5%) include: nausea, diarrhea, constipation, vomiting, injection site reactions, headache, low blood sugar, heartburn, fatigue (sleepiness), dizziness, stomach-area pain, increased lipase (a pancreatic enzyme), upper stomach-area pain, fever, and stomach infection (gastroenteritis)
