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SIA within the glycocalyx regulates Nrf2 mediating signal transfer by fluid shear force in the vascular endothelium, thereby regulating the endothelium's redox state [47]

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Rather, a recent study [103] in cyclists undergoing strenuous physical training observed improved physiological adaptation with a week of oral NAC while several other studies [72, 104] have found increased signaling cytokines such as TNF- with NAC supplementation compared to a placebo, despite improved performance