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Left uncontrolled, it can cause heart disease (heart failure, heart attack), stroke, end stage kidney disease, high cholesterol levels, nerve damage (neuropathy), eye damage (cataracts, diabetic retinopathy, and blindness), digestion problems (gastroparesis), erectile dysfunction, skin infections, frequent urinary tract infections, and dental infections and gum disease

MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a short peptide naturally produced by mitochondria

This mechanism slows gastric emptying, reduces appetite, and alters how the digestive tract processes food