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A 2.5 mg track has short direct data and real-world support for stable maintainers, but continuing tirzepatide has much stronger evidence than stopping. At week 112, stepping down to 5 mg preserved 16.6% weight loss versus 21.9% on the top dose and 9.9% on placebo

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Most reported side effects are mild and temporary , with users occasionally experiencing: Injection site reactions : Redness, swelling, or localized discomfort Headaches or dizziness Gastrointestinal issues : Nausea or mild stomach discomfort These effects typically resolve on their own

Gagliardi AMZ, Gomes Silva BN, Torloni MR, et al