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In zinc deficient rats, kidney functions are compromised due to structural abnormalities, including reduced number of nephrons and renal fibrosis, and functional impairments, such as reduced glomerular filtration rate and proteinuria [458]
Orphanet J Rare Dis 18(1):281 Haijes HA et al (2020) Understanding acute metabolic decompensation in propionic and methylmalonic acidemias: a deep metabolic phenotyping approach
509 AS-252424 is a specific and targeted ACSL4 inhibitor that binds directly to the glutamine 464 of ACSL4 to inhibit its enzymatic activity, thereby inhibiting lipid peroxidation and ferroptosis, effectively alleviating ferroptosis-mediated organ damage in mouse models, including I/R-induced kidney injury and acute liver injury
