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In hepatocellular carcinoma (HCC), LCACs are effectively loaded into the mitochondria of lymphocytes, resulting in the inhibition of invariant natural killer T (iNKT) cell expansion and the promotion of their senescence while simultaneously facilitating tumor evasion of immune surveillance [66]

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The study showed that switching from sitagliptin to oral SMG maintained HbA1c reductions, helped more patients achieve HbA1c targets with less use of additional glucose-lowering medications, and resulted in additional body weight reductions