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In two large-scale HA studies by Yamamoto et al., one in an adult and one in a paediatric cohort, symptoms were reported in 40.7% and 22.3% of the patients, respectively [6, 18]

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7).7,8,23,51,72 This is a finding that can support diagnosis of melanoma and that can only be assessed in biopsies that include the nail plate.1,7,11,23 It appears that the presence of a lymphocyte infiltrate in subungual intraepidermal melanocytic lesions is an important criterion for malignancy, as such an infiltrate is almost never found in subungual melanocytic nevi (Fig

in preventing vasoconstriction and platelet aggregation