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Several FXR agonists that have been assessed in clinical trials and their effects are: Obeticholic Acid (OCA): A derivative/synthetic variant of bile acid, it improves insulin sensitivity, liver inflammation, hepatocellular ballooning and reduces fibrosis (218)

Dulaglutide (LY2189265) is a synthetic peptide analog of glucagon-like peptide-1 (GLP-1) hormone

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That dual action is the likely reason Mounjaro produced an average weight loss of 20.2%, compared with 13.7% for the standard Wegovy injection, in their head-to-head trial