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Although combined therapy is still not common practice because of the relatively recent regulatory approval, these studies highlight the potential of dual GLP-1 RA + SGLT2i therapy to synergistically reduce cardiovascular disease and decelerate renal decompensation [75]

A provider should review risk factors before treatment

GLP-1 receptor agonists such as semaglutide are contraindicated in individuals with a personal or family history of medullary thyroid carcinoma or MEN 2, and should be avoided during pregnancy and breastfeeding