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[24] [25] It's important to note that while both medications can affect lipid parameters, large clinical trials (AIM-HIGH and HPS2-THRIVE) have not demonstrated cardiovascular outcome benefits from adding niacin to statin therapy

NAD+ helps fuel the cellular machinery that peptide signals rely on, so a physician designed plan may combine them under supervision

Additionally, any medicine with a 'narrow therapeutic index'where a small change in absorption can have a significant clinical impactrequires careful management

Pills are a reasonable choice for maintenance when your levels are already healthy and you simply want to keep them there