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Provider continuity - Will you see the same prescriber for follow-ups, or different providers each time

Others have demonstrated that the positive outcomes of obesity surgery (i.e., changes in body weight and improved glucose homeostasis) are sustained in mice in the absence of GLP-1R or Y2-R, or both GLP-1R and Y2-R 66,67

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The profound anatomical and pathophysiological disparities between these models and human disease create a significant translational gap. Acknowledging these limitations is key to interpreting preclinical data cautiously and designing more relevant experimental paradigms