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4.1 Bacterial infections Sepsis is one of the most recognized life-threatening dysfunctions that is caused due to infections and is the leading cause for mortality in non-cardiac ICUs (intensive care units) around the world

That nuclear translocation under metabolic stress is documented in the published literature: a peer-reviewed study in Cell Metabolism demonstrating that MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress in an AMPK-dependent manner describes the exact mechanism

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London: Global Science Books Ltd (2006) pp