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A large difference in basal concentrations of ergothioneine in whole blood was observed in a pharmacokinetic study by Cheah and colleagues (61) , who also noted that participants with the highest basal levels of ergothioneine also appeared to take up more of the supplemented ergothioneine

Methylene blue can lower blood pressure, so people with hypotension (low blood pressure) must be monitored closely by a healthcare professional or avoid use

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