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For instance: people with obesity are more likely to develop type 2 diabetes people with obesity are at an increased riskof developing Alzheimers later in life people with type 2 diabetes are also more likely to develop Alzheimers disease Alzheimers disease is associated with insulin resistance in the brain, with some scientists referring to Alzheimers as type 3 diabetes obesity, type 2 diabetes, and Alzheimers all involve inflammation, and GLP-1 agonists have an anti-inflammatory effect studies in animal models of dementiahave shown that GLP-1 agonists can protect rats brains from damage

Long-term use of these medications can result in nutrient deficiencies, such as vitamin B12 and magnesium, increased risk of bone fractures, kidney disease, and even gastric cancer in some cases

Cells 11 , (2022)

A retrospective matched cohort study found a significantly higher risk of NAION among people with diabetes and those with overweight or obesity taking semaglutide compared with those not on GLP-1 receptor agonist treatment