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These medications are complemented by a reduced-calorie diet and exercise regimen

By delivering retatrutide preferentially to the brain, researchers might achieve appetite suppression and metabolic regulation through central mechanisms while minimizing peripheral GI receptor activation

This suggests that the peptide may offer broader metabolic benefits beyond weight loss

Acknowledgments We would like to thank the Italian Society for Pediatric Endocrinology and Diabetes (ISPED) for its support to the Genetic Obesity Study Group, which is joined by most of the authors