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For individuals with a body mass index (BMI) of 30 kg/m or above (or 27.5 kg/m for people from South Asian, Chinese, other Asian, Middle Eastern, Black African, or African-Caribbean backgrounds), NICE recommends considering pharmacological interventions alongside lifestyle changes when dietary and exercise modifications alone have been insufficient

This study showed that GLP-1 receptor agonist use was associated with markedly diminished risks of cirrhosis (aHR: 0.72, 95%CI: 0.66-0.79) and HCC (aHR: 0.65, 95%CI: 0.56-0.76) compared to non-use throughout a mean observation period of 4.8 years, with benefits observed across different baseline liver disease stages [57]