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Whether peripheral indices of abnormal metabolites reflect similar changes in the brain and/or are related to presumed brain events are frequently raised by the reviewers in the grant applications and manuscript submissions

(2) Torres AE, Lyons AB, Hamzavi IH, Lim HW

That said, these effects are not yet well established clinically, and more research is needed to determine whether they are directly caused by the medication or influenced by factors such as weight loss, metabolic changes, or individual physiology

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), including exenatide, liraglutide, and semaglutide, have shown promise in reducing body weight, improving glycemic control, and slowing the progression of cardiovascular and kidney diseases