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Treatment modification How easy is it to adjust dosing

If you have diabetes, take insulin or other medications, have kidney disease, are pregnant, have a history of disordered eating, or have severe symptoms, work with your healthcare provider

155 Additionally, targeting bile acid metabolism, such as through bile acid sequestrants and farnesoid X receptor agonists, has shown promise in preclinical models by reducing bile acid accumulation and hepatotoxicity

Briefly, flash-frozen tissue samples were homogenized in ice-cold PBS containing 2 mM EDTA (1 ml PBS/EDTA per 10 mg tissue) using a Dounce homogenizer