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Glucagon-like peptide 1 and glucose-dependent insulinotropic peptide receptor agonists protect synaptic plasticity in animal models of Alzheimers disease The previous section showed that GLP-1 and GIP signaling has direct effects on synaptic transmission and LTP in the hippocampus

2 Mechanisms of action and ongoing therapeutic innovations in GLP-1 receptor agonists All GLP-1 RAs mimic the endogenous hormone GLP-1, binding to GLP-1 receptors (GLP-1 Rs) distributed in pancreatic islets, the gastrointestinal tract, and the brain

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Nature Biotechnology, 40 , 13411348