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In the STEP trials, semaglutide 2.4mg weekly resulted in mean weight reductions of 1517% over 68 weeks, whilst tirzepatide in the SURPASS trials showed reductions of 1520% (Kushner et al
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The long half-life of semaglutide (approximately one week) means that after seven days, about half of the medication is still in your system
The US Food and Drug Administration on Friday approved drugmaker Novo Nordisks application to add cardiovascular benefits to the medicines label, making it the first weight-loss drug to also be cleared to reduce the risk of heart attack, stroke or heart-related death in people at higher risk of these conditions
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