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In the colon, unabsorbed monosaccharides, polysaccharides, and non-digestible carbohydrates (fiber, resistant starch) are metabolized by bacterial fermentation into short-chain fatty acids [260,264]that bind free fatty acid receptors 2 and 3, resulting in GLP-1 secretion

GLP-1 (Glucagon-Like Peptide-1)

Similarly, while the starter doses of Wegovy, 0.25mg and 0.5mg, accounted for 29% and 21% of shortage reports respectively in August, the lower doses of Zepbound, 2.5mg and 5mg, accounted for less than 4% and 3% respectively