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( A ) Immunofluorescent staining showing increased levels of Ser15-phospho-p53 in the nucleus of senescent TM3 Leydig cells

Regulates Gene Expression: Research suggests it can positively affect the expression of hundreds of genes involved in skin repair while downregulating genes linked to chronic inflammation

The continuous production of ONOO could suppress the activity of glutathione reductase by nitration modification, thus collectively reducing detoxification and blocking DNA damage repair

Cancer is often driven by oxidative DNA damage, and autoimmune diseases can result from chronic oxidative stress-induced inflammation