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Additionally, impaired GABA synthesis, due to glutamic acid decarboxylase (GAD1) dysfunction, diminishes synaptic GABA levels, further contributing to excitability [4]

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The results showed speed of processing not only improved in the blueberry intervention group but blueberries also restored speed of processing to the level of the control group that had no reported cognitive issues

Thus, unlike previous in vitro biochemical studies or metabolic engineering efforts, which had excluded arGSTs, we set out to confirm our hypothesis by performing coupled enzymatic reactions with 3,4- cis -leucocyanidin ( 6 ) combining clarified Escherichia coli cell lysates expressing At LDOX and the well-studied arGST Ph AN9 from petunia