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Transcellular permeability Given the integrity of cellular structures and junctional proteins between ECs, it is typical for gases and small lipid-soluble molecules with molecular weights under 400 Da to be able to passively diffuse across the BBB [22]

Peptide microarray binding assay The microarray slides before use were blocked for 60 min in 5% (w/v) skimmed milk powder (Carl Roth) in phosphate-buffered saline (PBS

In addition, it has been shown that biotin administration might be effective in some neurological diseases

Factors affecting the lymphatic transport of penclomedine (NSC-338720), a lipophilic cytotoxic drug comparison to DDT and hexachlorobenzene