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Heart palpitations are reported across the entire class of GLP-1 receptor agonists, including semaglutide and tirzepatide

The Batsis/Prado review reports lean mass loss as a proportion of total weight lost

[PubMed] [5] M

The preferred first-line opioids are: hydromorphone at low doses (1 mg oral or 0.4 mg intravenous) or oxycodone (2.5 mg oral) with more extended dose intervals, as well as intravenous fentanyl in hospitalized patients or patches in outpatients