This mechanistic overlap explains why combining them may not produce additive benefitsthe GLP-1 receptor agonist effect of Rybelsus is already maximal, and adding a DPP-4 inhibitor to preserve endogenous GLP-1 (which is already being mimicked by semaglutide) offers limited additional advantage
That's slightly inconvenience
Rather than treating labs as a checkbox or an optional add-on, Meto built its entire GLP-1 pathway around a single, purpose-designed metabolic panel that consolidates every guideline-recommended biomarker CMP, HbA1c, full lipid panel, TSH, CBC, eGFR, ALT/AST, fasting insulin, and hs-CRP into one blood draw
For a related perspective on long-term weight stability, see how to maintain weight loss after tirzepatide