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How To Know Your New Dose Is Working Signs that tirzepatide dosing is appropriately matched for you may include: More stable appetite signals Consistent weekly weight trends Good energy throughout the day Fewer digestive side effects Feeling full with smaller portions If you experience significant nausea, fatigue, or rapid changes that feel uncomfortable, your dose may need to be adjusted or extended at a lower level

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Your diabetes team will balance the benefits of glucose lowering against this consideration, potentially adjusting medication doses more conservatively if you have advanced eye disease