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52 In addition, most cancer cells are extremely vulnerable to glucose withdrawal, 53, 54, 55, 56, 57, 58, 59 a feature they owe to metabolic reprogramming, leading to constitutively active proliferation pathways and glucose addiction

Vascular cognitive impairment and dementia in type 2 diabetes mellitus: An overview

It has been suggested that this effect is mediated by a reduction in endocannabinoid and arachidonic acid levels in the LSc and decreased synaptic dopamine levels (44)

Likewise, loss of IGF1 signal reduces the expression of mitochondrial biogenesis markers ( PGC1 , TFAM ) in the steroidogenic cells of prepubertal testis (Radovic et al., 2019)