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The third, and most ubiquitous theme, was a change in eating behaviours, both physical, with reduced appetite and increased satiety, as well as psychological, with increased control of eating, and reduction in cravings, comfort eating and food obsession

The progression from single to dual to triple agonism represents genuine innovation, not marketing hype

Randomized trials need to be designed to test that hypothesis directly, not inadvertently suppress it through exclusion criteria