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111 Although the antitumor effect of CR has been confirmed, the underlying mechanism remains unclear

This epigenetic derepression allows senescence-promoting gene expression to increase even when SIRT1 and FOXO3 protein activity is nominally intact a mechanism by which methylation cycle impairment undermines the longevity gene regulatory program from the chromatin level

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demonstrated that the long-term ingestion of high-flavanol cocoa provided significant photoprotection against UV-induced erythema, suggesting the importance of antioxidants in skin protection