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It has at times been granted a food-ingredient designation, which is not the same as approval to treat a medical condition

In Canada, synthetic injectable peptides are generally regulated as prescription drugs under the Food and Drugs Act, and Health Canada has issued public advisories (April 2026 and earlier) cautioning that unauthorized injectable peptide products are illegal regardless of whether they are labelled 'for research use only.' Research-grade AOD-9604 supplied by Koipeptides is intended for in vitro laboratory study only and is not authorized for any human or veterinary application

Hydroxocobalamin has a characteristic red colour, which is normal and may temporarily tint the urine pink or red for a day or two after injection

There is no established upper tolerable limit for B12 intake, though adverse reactions can occur in some individuals