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78,79 In addition, rare de novo mutations of CHD8, SCN1A, SCN2A, SYNGAP1, ARID1B, GRIN2B, DSCAM, TBR1, KATNAL2, LAMC3 and NTNG1 have been identified, with strong evidence for their association with ASD

It is proposed that such a disruption of BBB permeability produces a vicious circle in which incremental reductions in cerebral perfusion accelerates the neurodegenerative process thus facilitating further drops in cerebral perfusion [11,26,27]