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Start your intake Medications That Reduce GLP-1 Efficacy Through Gastric Mechanisms Anticholinergic drugsincluding certain antihistamines, antispasmodics, and some antidepressantsslow gastric motility, potentially reducing GLP-1 absorption and effectiveness

Unreconstituted Ipamorelin vials should be stored refrigerated at 28C in lyophilized (powder) form

Rapid heart rate or palpitations Any changes to heart rate that are new or worsening after starting GLP-1 treatment are worth reporting to a doctor, particularly for patients with existing cardiac conditions

The upcoming drug Retatrutide goes a step further and acts on three targets GLP-1, GIP, and glucagon, tackling obesity more effectively at 24 per cent, says Dr V Mohan, chairman, Dr Mohans Diabetes Specialities Centre, Chennai