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In summary, both psychostimulant and non-psychostimulant ADHD treatments ultimately function by modulating the levels and activity of dopamine and norepinephrine in the brain, particularly in areas associated with attention, impulse control, and hyperactivity [40]

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Considering the absence of a clear NLS (nuclear localization signal), this nuclear localization is more likely due to a passive diffusion through nuclear pore rather than to a specific targeting