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Furthermore, it is also expressed in chondrocytes and is particularly abundant in the growth plate [145]

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A 2012 study published in Journal of Pharmacology and Experimental Therapeutics demonstrated that a seven-day dihexa dosing protocol produced cognitive improvements in rodent models that persisted for at least 30 days post-treatment, despite the compound being undetectable in plasma within 12 hours of the final dose

Both wild-type and hepsin / mice received an intraperitoneal injection of 2APB (20 mg/kg), followed by a dose of APAP (500 mg/kg) 2 h later (Fig