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This neurological shift happens gradually over days and weeks, which is why the lowest dose serves as your foundation rather than your final therapeutic dose

The treatment duration should be tailored to achieve and maintain the desired weight loss while ensuring patient safety

Tirzepatide (Mounjaro), a dual GIP/GLP-1 receptor agonist, shows dose-dependent nausea rates, ranging from approximately 12-18% at lower doses to higher rates at doses used for weight management, as demonstrated in the SURPASS-2 trial comparing it with semaglutide

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