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Physiology of Appetite Regulation The anorexigenic (satiety-promoting) and orexigenic (hunger-stimulating) pathways consist of an intricate network of hormones, neurotransmitters, and neural circuits, all intricately interwoven to maintain our bodys energy balance The anorexigenic pathway is a complex signaling system that regulates food intake and energy balance

Stock solutions of test compounds that are water soluble were made up at 20 times the final assay concentration in buffer (including glucose, GEP44, GEP12, exendin-4, PYY 1-36 and insulin)

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( A and B ) Mice weight and blood glucose measured at 7 am in the month after SG