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Thyroid status is one of the components of immunomodulating effect in AITD In physiological and pathological conditions, the interaction between TG - 3,3,5,5-tetraiodo-L-thyroxine (T4) and 3,3,5-triiodo-L-thyronine (T3) and the immune system has been established

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It has also been known for 80+ years that carnosine is a key intra-cellular buffer due to its nitrogen containing imidazole side ring, which can accept (buffer) H + (Bate-Smith, 1938), and slow the decline in muscle pH during intense exercise (Baguet, Koppo, Pottier, & Derave, 2010)

& Mehendale, A