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a l , Dose-dependent inhibition curves of NAMs on wild-type GLP-1R ( a ) or GLP-1R mutants ( b j ), as well as wild-type GCGR ( k ) or the F345 6.36b C mutant ( l )

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Glutathione is found almost exclusively in its reduced form, since the enzyme that reverts it from its oxidized form, GSSG, is constitutively active and inducible upon oxidative stress