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Passage of bile acids through the enterocyte activates FXR, which promotes the synthesis of fibroblast growth factor 19 (FGF19), which also circulates through the portal vein to the liver where it activates fibroblast growth factor-receptor 4 resulting in inhibition of bile acid synthesis
The temporary discomfort of nausea is often outweighed by the significant health benefits these medications can providebut you dont have to suffer through it alone
It is a poor inhibitor of PG synthesis in peripheral tissues, but more active on COX in the brain
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