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Retatrutide, a triple-agonist (GLP-1, GIP and glucagon), is in late-stage trials and has produced even more weight loss in early data up to 24% at 48 weeks in phase 2

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It found that despite rapid weight-loss seen within the GLP-1 exposure group, as shown in the chart below, calorie cuts and average weight-loss results remained in line with other participants using alternative treatments

Akkermansia muciniphila upregulates genes involved in maintaining the intestinal barrier function via ADP-heptose-dependent activation of the ALPK1/TIFA pathway