semaglutide didn't work for me semaglutide doesn't seem to be working Why Doesn't GLP-1 Work for Me? Causes If you’re taking a GLP-1

Opposing effects on body weight: Prednisolone is well-known for causing weight gain through multiple mechanisms, including increased appetite, fluid retention, and redistribution of body fat (particularly to the face, neck, and trunk)

Stand up slowly from sitting or lying positions, as postural hypotension (a drop in blood pressure upon standing) can be worsened by these medications

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The glucagon receptor's direct hepatic effects distinguish retatrutide from GLP-1 and GIP agonists, which lack direct hepatic receptor engagement