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Known as the incretin effect, GLP-1 and its synergetic sister hormone glucose-dependent insulinotropic polypeptide (GIP), are rapidly released by lower enteroendocrine L-cells (GLP-1) or upper enteroendocrine K-cells (GIP) in the gut following food intake and rising circulatory glucose levels to augment the glucose-stimulated release of insulin by pancreatic cells

The results indicated that all engineered fusion proteins showed a relatively high docking score, suggesting that they may have lower energy constraints for binding (Table 3)

A separate analysis found that semaglutide users had significantly lower 30-day, 3-month, and 1-year risk of joint-related outcomes, including stiffness, pain, swelling, and synovitis, compared to nonusers

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