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Ethical Issues The study was conducted following the Declaration of Helsinki and approved by the Institutional and Regional Ethical Committees of Faculty of Medicine, Tanta University (reference number: 36264PR1087/2/25) and had Clinical trial registration from Pan African Clinical Trial Registry (PACTR202504698770932)

doi: 10.1016/j.biochi.2014.04.001

Medications such as metformin [Glucophage], phentermine [Adipex-P], topiramate [Topamax], bupropion [Wellbutrin], and naltrexone [Revia] (sometimes used alone or in combination, [such as Contrave]) can be effective and are often available as inexpensive generics, sometimes for as little as $10 to $20 per month