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We showed that MDMA dramatically reduced mitochondrial trafficking in hippocampal neurons in a Tau-dependent manner, in which glycogen synthase kinase 3 activity was implicated

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Interpreted alongside observational data and mechanistic evidence, these findings support tirzepatide as an effective therapy for cardiovascular risk reduction in patients with T2D and established ASCVD or high CV risk, with benefits at least comparable to GLP-1RAs

Comparative studies on the safety and efficacy of orlistat against other weight-loss drugs suggest that the side effects linked to orlistat are generally minor and temporary [42]