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Both population and in vivo evidence indicate that oral Vitamin D supplementation increases cathelicidin levels in specific skin lesions, while topical Vitamin D analogues (e.g., calcipotriol) similarly enhance hCAP18/LL-37 expression in wound models, suggesting that correcting Vitamin D axis hyporesponsiveness may help reverse the age-associated phenotype of AMP deficiency and susceptibility [243, 244]

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People with certain health conditions, such as liver disease or a history of drug abuse, should use Dextromethorphan cautiously

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