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The UKPDS and DCCT studies established that every 1% A1C reduction corresponds to approximately 37% lower risk of microvascular complications (eye disease, kidney disease, nerve damage)

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Kroner et al (49) demonstrated that elevated iron levels in microglia promote phagocytosis and drive a harmful M1 phenotype, which triggers the release of pro-inflammatory factors such as TNF-, IL-1, IL-6 and nitric oxide (NO), causing neuronal damage

As a result of these findings, EMA recommended updating semaglutide product information to include NAION as a side effect with very rare frequency