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Nonetheless, considering the clinical relevance of GLP-1 therapies and their potential impact on energy balance beyond food intake and body weight, future studies should investigate whether GLP-1 agonists influence hypothalamic neuropeptide expression or signaling cascades in MC4R-deficient models

More than 65 percent of participants who took the 12 mg dose reached a BMI below 30 after 80 weeks, which means they were no longer classified as having obesity

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