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Taking it in the morning helps activate your metabolism early in the day, while post-workout use helps with muscle recovery and continued fat utilization

Kuwasawa-Iwasaki M, Io H, Muto M, Ichikawa S, Wakabayashi K, Kanda R, et al

The more accurate concern is that rapid weight loss, reduced lean mass, and decreased mechanical loading may create bone health concerns in some populations, particularly when resistance training is absent