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As in all surgical procedures appropriate measures should be taken to minimize trauma to the cornea and other ocular tissues

30 An early peak in acute pancreatitis also occurred within the first 60 days of starting therapy in the SCALE trial

For CRISPRa to work, single-guide RNAs (sgRNA) are designed to target regions between 1 to 1000 bp upstream of the transcription start site (TSS) within the promoter region of the target gene